Human brain tissue is an absolute requirement for research in neurological diseases that can ultimately lead to prevention, amelioration and cure of these diseases. It is indispensable for:
confirmation of clinical diagnosis
full characterization of clinical, pathological, molecular, and genetic aspects of neurological diseases
studies of the involvement of biomolecules and their interactions using histological staining and ultrastructural techniques.
Although some details of the disease process may be examined in animal and cell-based models, unfortunately, there are no satisfactory models for many neurological diseases, including Alzheimer’s disease. Hence, cutting edge research requires securing well-characterized human brain tissue. To tackle this enormous problem, a concerted effort by clinical and basic science researchers is required.
Research using human brain tissues has made, and is expected to continue to make, significant contributions to discovery of the causes, treatments, and the ultimate cures for a number of diseases affecting the nervous system. In fact, many drugs currently used to treat the symptoms of Alzheimer’s disease and Parkinson’s disease were developed solely as a consequence of examining post-mortem brain tissues of affected individuals and comparing them to normal brain tissues (Bartus et al., 1982; Coyle et al., 1983; Birkmayer and Hornykiewicz, 1998; Ehringer and Horneykiewicz, 1998; Atri, 2011).
To be able to examine and work with brain tissue from diseased and healthy individuals, it is imperative that well-characterized brain tissues be stored and made available to neuroscience researchers globally.